Evidence map›Paper›PMID 42449184›Full record

SynthesisOrthopaedic surgery2026

Systematic Review of Paraspinal Muscle Changes in Lumbar Spondylolisthesis: MRI and CT Insights.

Valerio D'Andrea, Caterina Bernetti, Federico Greco, Claudia Volterrani, Carlo C Quattrocchi, Paul M Parizel, Johan Van Goethem, Gianfranco Di Gennaro, Bruno Beomonte Zobel, Carlo A Mallio

Abstract readSystematic Review
In one paragraph

Synthesis in Orthopaedic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valerio D'AndreaFondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.ORCID https://orcid.org/0009-0007-3583-7563
Caterina BernettiFondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Federico GrecoResearch Unit of Radiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Claudia VolterraniFondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Carlo C QuattrocchiCentre for Medical Sciences-CISMed, University of Trento, Trento, Italy.
Paul M ParizelRoyal Perth Hospital (RPH), Perth, Australia.
Johan Van GoethemDepartment of Radiology, Antwerp University Hospital, Edegem, Belgium.
Gianfranco Di GennaroDepartment of Health Sciences, Chair of Medical Statistics, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Bruno Beomonte ZobelFondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Carlo A MallioFondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpondylolisthesis is a frequently encountered condition in orthopedics, requiring dynamic stability maintained primarily by the paraspinal muscles. This systematic review evaluates the cross-sectional area (CSA) and fat infiltration (FI) of paraspinal muscles-specifically the multifidus, erector spinae, and psoas major-in lumbar spondylolisthesis (LS) to understand their roles in spinal stability and progression in degenerative and isthmic forms.

methodsFollowing PRISMA guidelines, PubMed, Cochrane, and Scopus were searched as of September 2024. Fourteen retrospective studies using MRI/CT imaging met inclusion criteria, focusing on CSA and FI in LS. Data were extracted from studies that assessed spinal instability through vertebral slippage measurements or comparisons with asymptomatic controls.

resultsThe findings indicate that reduced CSA and increased FI in paraspinal muscles, especially the multifidus, are associated with spinal instability and progressive vertebral slippage. Several studies reported reductions in CSA and increases in FI in patients with spondylolisthesis, although methods and anatomical levels varied across studies. Compensatory hypertrophy of the erector spinae and psoas major was observed, particularly in isthmic cases.

conclusionsThese findings support the potential role of muscle health in maintaining spinal stability and suggest that targeted rehabilitation strategies addressing paraspinal muscle alterations may improve clinical outcomes in patients with LS.

Indexed as

Lumbar VertebraeMagnetic Resonance ImagingParaspinal MusclesSpondylolisthesisHumansTomography, X-Ray Computedcross‐sectional areaCTMRIparaspinal musclesspondylolisthesis

Identifiers

PMID42449184
PMCPMC13398913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.