Evidence map›Paper›PMID 42449103›Full record

ArticleNature communications2026

Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.

Tingting Qin, Rachael Bogle, Rundong Jiang, Mrinal K Sarkar, Yuli Cai, Mehrnaz Gharaee-Kermani, Jennifer Fox, Xianying Xing, Sahiti Marella, Mio Nakamura and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Tingting QinGilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3810-7578
Rachael BogleDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3544-3023
Rundong JiangDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0006-8296-4912
Mrinal K SarkarDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8505-4259
Yuli CaiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0009-7964-7651
Mehrnaz Gharaee-KermaniDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2177-2427
Jennifer FoxDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Xianying XingDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sahiti MarellaDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mio NakamuraDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Emanual MaverakisPHYSIOSEQ, Sacramento, CA, USA.ORCID http://orcid.org/0000-0002-6294-6294
Stephanie T LePHYSIOSEQ, Sacramento, CA, USA.
Alexander A MerleevPHYSIOSEQ, Sacramento, CA, USA.
Alina I MarusinaPHYSIOSEQ, Sacramento, CA, USA.
Cory L SimpsonDepartment of Dermatology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3933-6404
Arti PariharDepartment of Dermatology, University of Washington, Seattle, WA, USA.
Connor HillJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.
He LiJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.
J Michelle KahlenbergDepartment of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4006-8945
Dawn M WaterworthJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.ORCID http://orcid.org/0000-0002-9226-1317
Nina SabinsJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.
Lloyd S MillerJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.ORCID http://orcid.org/0000-0002-8332-2210
Tom C FreemanJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.
Monica Wl LeungJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.
Marta E PolakJohnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA.ORCID http://orcid.org/0000-0003-2878-476X
Lam C TsoiGilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.ORCID http://orcid.org/0000-0003-1627-5722
Allison C BilliDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. acbilli@med.umich.edu.ORCID http://orcid.org/0000-0001-7115-9113
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.ORCID http://orcid.org/0000-0002-0080-0812

Funding

University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Immunogenomics and Systems Biology CoreUC2AR081033 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson, Lam Cheung Tsoi · 2022 to 2026
$3.3M
NIAMS NIH HHS P30 AR075043NIAMS NIH HHS UC2 AR081033U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1P30AR075043U.S. Department of Health & Human Services | National Institutes of Health (NIH) UC2 AR081033
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a common chronic inflammatory skin disease with heterogeneous and poorly understood mechanisms. We perform single-cell RNA sequencing of lesional (LAD) and non-lesional (NAD) skin from 42 AD patients and 23 healthy controls (HC). Keratinocytes (KCs) are the predominant disease-relevant cell type. In healthy skin, KC differentiation follows a linear trajectory from basal KCs through seven differentiated stages to terminal keratinized cells. In LAD, this process is disrupted, showing a reversed terminal transition mainly driven by DK7 cells. APOD, LYZ and SERPINB4 emerge as LAD-specific regulators linked to IL-13/IL-22 responses, ER stress and oxidative damage. Mitochondrial and ER dysfunction are specifically enriched in LAD DK6 cells, indicating a key pathogenic compartment. Spatial transcriptomics and cell-cell interaction analysis further identify LAD-specific TWEAK signaling from IL-13

Indexed as

Cell DifferentiationDermatitis, AtopicKeratinocytesTranscriptomeFemaleGene Expression ProfilingHumansInflammationMaleSignal TransductionSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisSkin

Identifiers

PMID42449103
PMCPMC13487195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.