Evidence map›Paper›PMID 42449092›Full record

ArticleThe protein journal2026

Tyrosinase Structural Perturbation and Functional Inhibition by an Ostrich-Derived Keratin-Diospyros lotus Nanobiocomposite: Biochemical Mechanism and Melanoma Cell Response.

Marzieh Karimian Amroabadi, Azadeh Hekmat, Asghar Taheri-Kafrani, Aghdas Banaei

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Article in The protein journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marzieh Karimian AmroabadiDepartment of Biology, SR. C., Islamic Azad University, Tehran, Iran.
Azadeh HekmatDepartment of Biology, SR. C., Islamic Azad University, Tehran, Iran. ahekmat@iau.ac.ir.ORCID http://orcid.org/0000-0003-0123-1575
Asghar Taheri-KafraniDepartment of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Aghdas BanaeiDepartment of Nanoscience and Biophysics, Research Institute for Applied Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to develop a bioactive keratin-based nanocomposite for modulation of tyrosinase structure and function. Keratin nanoparticles (KNPs) were synthesized from ostrich feathers and functionalized with Diospyros lotus leaf extract (DLE). Physicochemical analyses (XRD, FT-IR, ζ-potential, DLS, TEM) confirmed a stable surface-functionalized nanocomposite, evidenced by a ζ-potential shift from - 16.9 mV to -40.9 mV and increased particle sizes (TEM: 87.1 to 113.3 nm; DLS: 275.3 to 325.2 nm). DLE-KNPs exhibited dose-dependent inhibition of mushroom tyrosinase with an IC

Indexed as

DiospyrosEnzyme InhibitorsKeratinsMelanomaMonophenol MonooxygenaseNanocompositesPlant ExtractsAnimalsApoptosisCell Line, TumorFeathersHumansPlant LeavesEnzyme InhibitorsKeratinsMonophenol MonooxygenasePlant ExtractsA-375 cellsDiospyros lotus L. extractKeratin nanoparticlesNatural compositeTyrosinase inhibitor

Identifiers

PMID42449092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.