Evidence map›Paper›PMID 42449010›Full record

ArticleMolecular imaging and biology2026

Collagen-binding ⁶⁸Ga-CBP8 PET/MR in Deep Pelvic Endometriosis: First-in-human Application.

Antonino Andrea Blandino, Peter Caravan, Anuradha S Shenoy-Bhangle, Peter R Movilla, Elio Quiros, Mario V Russo, Michael J Misialek, Liran Domachevsky, Leo L Tsai, Onofrio Antonio Catalano

Erratum issued Registry-linked trialAbstract read
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In one paragraph

Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06377553 (PET/MRI Evaluation of Endometriosis Using Intercellular Matrix Radiopharmaceuticals), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06377553 enrolling by invitationnot on this map

PET/MRI Evaluation of Endometriosis Using Intercellular Matrix Radiopharmaceuticals

TypeobservationalSponsorMassachusetts General HospitalRan2025 to 2029Enrolled60ConditionsEndometriosis, EndometriomaArmsRadiotracer Injection, Imaging, Rectal Ultrasound Gel Injection
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Antonino Andrea BlandinoDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.ORCID http://orcid.org/0009-0004-6017-5467
Peter CaravanDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-3179-6537
Anuradha S Shenoy-BhangleDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0001-8957-6548
Peter R MovillaCenter for Minimally Invasive Gynecological Surgery (MIGS), Newton-Wellesley Hospital, Newton, MA, USA.
Elio QuirosDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.ORCID http://orcid.org/0009-0009-4656-1317
Mario V RussoDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Michael J MisialekDepartment of Pathology, Newton-Wellesley Hospital, Newton, MA, USA.
Liran DomachevskyDepartment of Nuclear Medicine, Sheba Medical Center, Tel-Hashomer, 31 Emek Ha'ela Street, Ramat Gan 52621, Israel.
Leo L TsaiDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0001-6941-7443
Onofrio Antonio CatalanoDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA. onofriocatalano@yahoo.it.ORCID http://orcid.org/0000-0001-7733-4138

Funding

Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
$325k
NIH Office of the Director S10OD028499
6 · The paper itself

Abstract

purposeTo evaluate the feasibility of collagen-binding ⁶⁸Ga-CBP8 PET/MR for the noninvasive detection of deep infiltrating endometriosis. MATERIAL AND

methodsA single-case exploratory application of ⁶⁸Ga-CBP8 PET/MR was conducted in a patient with endometriosis as a preliminary step toward a larger IRB-approved prospective study. Imaging was performed 60 min after intravenous administration of ⁶⁸Ga-CBP8. Fused PET/MR images were qualitatively assessed for focal tracer uptake exceeding background. Surgical pathology, assessed in a blinded fashion, served as the reference standard.

resultsA 32-year-old woman with history of endometriosis completed the examination without adverse events. PET/MR demonstrated focal ⁶⁸Ga-CBP8 uptake corresponding on MR to a T2-hypointense plaque located between the left adnexa and the sigmoid colon, suspicious for deep pelvic endometriosis with bowel involvement. Surgical pathology confirmed endometriosis infiltrating the colonic muscularis mucosae and pericolonic tissue with dense fibrosis.

conclusion⁶⁸Ga-CBP8 PET/MR is a feasible and promising technique to noninvasively detect deep infiltrating endometriosis, warranting validation in larger prospective studies.

trial registrationClinicalTrials.gov, NCT06377553. Date of first enrollment: February 5, 2025. Registered April 22, 2024.

Indexed as

Collagen type IEndometriosisFeasibility studiesFibrosisGallium radioisotopesPositron-emission tomography magnetic resonance imaging

Identifiers

PMID42449010

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