Evidence map›Paper›PMID 42448931›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Mangiferin mitigates tacrolimus-induced nephrotoxicity in rats via modulation of oxidative stress, NLRP3 inflammasome, VEGF signaling, and PI3K/AKT/PTEN-mediated autophagy and apoptosis.

Naif Alharbi, Omnia A Nour, Mirhan N Makled, Manar Nader

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Naif AlharbiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Omnia A NourDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Mirhan N MakledDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Manar NaderDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. manarahna@mans.edu.eg.ORCID http://orcid.org/0000-0002-8590-2622

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tacrolimus (TAC), a calcineurin inhibitor commonly used as an immunosuppressant in organ transplantation, is often limited by its nephrotoxic effects. This study explored the protective potential of mangiferin (MF), a naturally occurring glucosylxanthone, against TAC-induced nephrotoxicity in rats. Thirty-six rats were allocated into six groups: control, TAC, MF

Indexed as

Caspase-1MangiferinNephrotoxicityNLRP3PI3K/AKT/PTENTacrolimus

Identifiers

PMID42448931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.