Evidence map›Paper›PMID 42448891›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Optimizing FAPI homodimers for theranostic applications: The impact of the linker design in DOTAGA.Glu

Naveen Kumar, Adrianna Bilinska, Elena Menéndez, Sarah Stephan, Frank Rösch, Axel Rominger, Eleni Gourni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naveen KumarDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Adrianna BilinskaDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Elena MenéndezDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Sarah StephanDepartment of Chemistry-TRIGA site, Johannes Gutenberg-University Mainz, Mainz, Germany.
Frank RöschDepartment of Chemistry-TRIGA site, Johannes Gutenberg-University Mainz, Mainz, Germany.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Eleni GourniDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland. eleni.gourni@insel.ch.ORCID http://orcid.org/0000-0003-2198-382X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study evaluated the imaging performance, tumor retention, and therapeutic potential of two new FAPI homodimers, DOTAGA.Glu

methodsDOTAGA.Glu

resultsAll radioligands showed > 99% radiochemical purity, high FAP affinity (K

conclusionDOTAGA.Glu

Indexed as

Drug DesignHeterocyclic Compounds, 1-RingPolyethylene GlycolsRadiopharmaceuticalsAnimalsCell Line, TumorFibroblast Activation Protein AlphaGallium RadioisotopesHumansLutetiumMicePositron Emission Tomography Computed TomographyRadioisotopesSingle Photon Emission Computed Tomography Computed TomographyTissue DistributionFibroblast Activation Protein AlphaGallium-68Gallium RadioisotopesHeterocyclic Compounds, 1-RingLutetiumLutetium-177Polyethylene GlycolsRadioisotopesRadiopharmaceuticalsCombination therapyEverolimusFAP inhibitorFractionated monotherapygallium-68Homodimeric FAPIlutetium-177

Identifiers

PMID42448891
PMCPMC13633386

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.