Evidence map›Paper›PMID 42448844›Full record

ReviewCommunications biology2026

Rational dsRNA design, scalable production and nanodelivery to enhance spray-induced gene silencing.

Guoning Zhu, Chao Xu, Tao Zhang

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guoning Zhu *State Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.
Chao Xu *Institute of Germplasm Resources and Biotechnology, Tianjin Academy of Agricultural Sciences, Tianjin, China.
Tao ZhangState Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China. tzhang@ms.xjb.ac.cn.ORCID 0009-0007-0264-5346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spray-induced gene silencing (SIGS) provides a sustainable, highly targeted alternative to chemical pesticides. This review summarizes recent advances in dsRNA technology through a design-to-delivery framework. Key focuses include bioinformatics-driven multi-target dsRNA design for improved stability and efficacy, cost-effective microbial and cell-free synthesis platforms for scalable production, and nanocarriers that protect dsRNA from degradation while enhancing delivery. Integrating rational design, efficient production, and precision nanodelivery will accelerate SIGS from laboratory concept to practical, eco-friendly tool for global crop protection and sustainable agriculture.

Indexed as

Gene SilencingNanoparticlesRNA, Double-StrandedRNA InterferenceRNA, Double-Stranded

Identifiers

PMID42448844
PMCPMC13369902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.