ArticleCommunications chemistry2026
Application of electron diffraction to rapid structural elucidation of crude reaction products.
Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Total Synthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic.Journal of the American Chemical Society · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The explicit confirmation of the identity of desired or side products of a chemical reaction often requires lengthy or iterative purification protocols, combined with multiple analytical procedures that could be restricted by the available sample quantity and purity, or might provide only qualitative information on the chemical composition. Product mixtures with overlapping spectroscopic signals, low solubility, reactivity in solution, poor crystallinity, and multiple sample preparation steps could pose further challenges and currently stand in the way of full automation of product characterization. Being capable of rapidly providing structural details down to atomic scale resolution from nanosized crystalline samples, three-dimensional electron diffraction (3D ED) (microcrystal electron diffraction) effectively overcomes several of these obstacles. Here, we demonstrate the potential for the application of 3D ED in the efficient and rapid characterization of reaction products that are difficult to characterize. Furthermore, the technology utilized in this paper comes with the benefits of reducing the carbon footprint of a synthesis procedure, eliminating redundant steps needed for common characterization methods, and providing a shortcut for characterization without increased costs. We suggest that, based on the speed and minimal sample requirements demonstrated here, coupling 3D ED/MicroED with automated synthetic workflows could help accelerate future drug discovery efforts.
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Registered trials
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