Evidence map›Paper›PMID 42448675›Full record

ArticleNature communications2026

Disrupting fumarylacetoacetate hydrolase by stratified nanoplatforms orchestrates metabolic-immune reprogramming and prevents post-ablation HCC relapse.

Zhiwen Hong, Xiaolong Liu, Rouhan A, Zengzhen Chen, Qianjiang Wu, Jixian Fu, Xue Guan, Can Wang, Xinghua Wang, Shan Jiang and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhiwen Hong *Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.ORCID http://orcid.org/0009-0008-1173-5615
Xiaolong Liu *Department of Interventional Radiology, Harbin Medical University Cancer Hospital, Harbin, China.
Rouhan A *Department of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Zengzhen Chen *State Key Laboratory of Cryogenic Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China.
Qianjiang WuDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Jixian FuDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Xue GuanAnimal Laboratory Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Can WangDepartment of Gynecologic Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Xinghua WangDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Shan JiangDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Bolong LiDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Zhaobo WangDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China.
Lei ZhangDepartment of Interventional Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China. tianwang.3000@163.com.
Xianwei MengState Key Laboratory of Cryogenic Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China. mengxw@mail.ipc.ac.cn.
Yali CuiDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China. yalicui68@126.com.
Tengchuang MaDepartment of Nuclear Medicine, Harbin Medical University Cancer Hospital, Harbin, China. matengchuang1988@126.com.ORCID http://orcid.org/0000-0002-0352-4526

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62405333National Natural Science Foundation of China (National Science Foundation of China) 82172041National Natural Science Foundation of China (National Science Foundation of China) 82572336
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) recurrence following microwave ablation poses a pressing clinical challenge, driven by metabolically adapted residual cells that establish an immunosuppressive tumour microenvironment. Our study identifies the post-ablation upregulation of fumarylacetoacetate hydrolase (FAH) as a crucial "metabolic checkpoint" promoting relapse. Elevated FAH expression results in increased fumarate levels within residual HCC cells, supporting tumour cell survival by enhancing energy metabolism while concurrently impairing CD8

Indexed as

Carcinoma, HepatocellularHydrolasesLiver NeoplasmsNeoplasm Recurrence, LocalAnimalsCD8-Positive T-LymphocytesCell Line, TumorFumaratesHSP70 Heat-Shock ProteinsHumansMetabolic ReprogrammingTumor MicroenvironmentFumaratesfumarylacetoacetaseHSP70 Heat-Shock ProteinsHydrolases

Identifiers

PMID42448675
PMCPMC13486681

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.