ArticleThe journal of allergy and clinical immunology. In practice2026
Asthma Burden in Mild Adult Asthma in the PEARL Survey: Asthma Control and Health Status.
Article in The journal of allergy and clinical immunology. In practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAsthma classified as "mild" is commonly assumed to have a low symptom burden and limited impact on quality of life.
objectiveTo characterize patient-reported asthma burden among adults with mild asthma identified using electronic health record-based criteria.
methodsA total of 3787 adults aged 18-85 years completed a survey assessing asthma burden. Asthma control and health-related quality of life (HRQOL) were measured using the Asthma Impairment and Risk Questionnaire (AIRQ) and the Veterans RAND 12-item Health Survey (VR-12), respectively. Investigator-developed items were used to assess symptoms, functional impact, and health care utilization in the prior year. Associations between patient characteristics and prespecified outcomes-very poorly controlled asthma in the past 2 weeks, symptoms ≥2 days/wk, and ≥2 patient-reported asthma-related emergency department (ED) or urgent care (UC) visits in the prior year-were evaluated using multivariable analyses.
resultsAsthma control was distributed across AIRQ categories as follows: 34.6% well controlled, 32.9% not well controlled, and 32.5% very poorly controlled. Patient-reported burden was notable: 27.6% reported symptoms at least a few times per week, 52.7% reported systemic corticosteroid use ever, and 41.4% reported ≥1 ED/UC visit in the prior year, including 19.7% with ≥2 visits. The mean [standard deviation] VR-12 scores indicated impaired HRQOL (physical component summary: 43.3 [9.7]; mental component summary: 44.7 [11.8]). Hispanic/Latino and Black/African American patients had higher risks of very poorly controlled asthma and ≥2 ED/UC visits in the prior year compared with non-Hispanic White patients.
conclusionsAmong surveyed adults with utilization-defined mild asthma and a recent asthma-related healthcare encounter, substantial patient-reported burden was observed across multiple domains.
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