Observational studyArquivos de neuro-psiquiatria2026
Transcranial Doppler findings in patients with COVID-19: a prospective observational study.
Observational study in Arquivos de neuro-psiquiatria, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
Background: Transcranial Doppler (TCD) is a diagnostic tool to detect real-time spontaneous microembolic signals (MESs) in intracranial circulation. Critically-ill coronavirus disease 2019 (COVID-19) patients may present an increased likelihood of MESs due to systemic inflammation and hypercoagulability. Objective: To assess the presence of MESs and other TCD parameters, including cerebral blood flow velocity (CBFV), pulsatility, and resistance indices, and to calculate the estimated cerebral perfusion pressure (eCPP) in patients with and without COVID-19. Methods: The TCD monitoring was performed for 1 hour in both middle cerebral arteries (MCAs) of adult patients in the Intensive Care Unit (ICU) with confirmed COVID-19 infection. The eCPP was calculated by multiplying the mean arterial pressure (MAP) by the ratio of end-diastolic velocity to mean CBFV, then adding 14 mmHg. Results: We evaluated 31 subjects: 11 intubated COVID-19 patients, 10 non-intubated COVID-19 patients, and 10 intubated non-COVID-19 patients. Patient ages ranged from 29 to 84 (median: 62; interquartile range [IQR]: 50-70) years, with 64.5% being male individuals. A total of 17 (54.8%) subjects died during hospitalization, and 2 patients (6.45%) lacked an ultrasonographic signal via the transtemporal window. No MESs were detected. A positive correlation was found between the resistance index of MCAs ( Conclusion: No spontaneous cerebral microemboli were observed in this cohort, but patients with higher direct bilirubin, CRP, aPTT, and D-dimer presented lower eCPP.
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