Evidence map›Paper›PMID 42447866›Full record

ArticleCell reports. Medicine2026

Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth.

Ximena Diaz Olea, Kristin Beede, Gabriel Pereira, David Scott, Christopher Petucci, Eric Martens, Dmitri Rodionov, Aagam Shah, Miguel P Martinez, Hyungsoo Kim and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Ximena Diaz OleaTranslational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Kristin BeedeDepartment of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Gabriel PereiraDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
David ScottSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Christopher PetucciPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric MartensDepartment of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Dmitri RodionovSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Aagam ShahTranslational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Miguel P MartinezDivision of Molecular Oncology & Immunology, the Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands.
Hyungsoo KimTranslational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Ashok Kumar SharmaHuman Microbiome Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Anthony MartinHuman Microbiome Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Tongwu ZhangDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD 20892, USA.
Mark B FariesThe Angeles Clinic and Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90025, USA.
Omid HamidThe Angeles Clinic and Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90025, USA.
Suzanne DevkotaDepartment of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Human Microbiome Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Andrei OstermanSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Simon KnottTranslational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Emile E VoestDivision of Molecular Oncology & Immunology, the Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands.
Nadim J AjamiDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jennifer WargoDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Amanda E Ramer-TaitDepartment of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. Electronic address: aramer-tai2@unl.edu.
Ze'ev A RonaiTranslational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: zeev.ronai@csmc.edu.

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
Rewired Signaling at the Nexus of Melanoma Metastasis and ResistanceR35CA197465 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RONAI, ZEEV A. · 2016 to 2022
$7.9M
REGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5M
Multi-strain, live biotherapeutics as adjuncts to checkpoint inhibitor therapyR21CA249822 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KIM, HYUNGSOO, RAMER-TAIT, AMANDA ELLEN · 2021 to 2022
$476k
NCI NIH HHS P30 CA036727NCI NIH HHS R21 CA249822NCI NIH HHS R35 CA197465NIDDK NIH HHS R01 DK030292
6 · The paper itself

Abstract

Study of gut microbiota control of anti-tumor immunity (ATI) identifies Bacteroides rodentium and the human-related Bacteroides uniformis species to be capable of inducing ATI and limiting melanoma development in germ-free (GF), complex microbiome, or wild-type (WT) mice. Enhanced CD8

Indexed as

BacteroidesMelanomaTryptophanAnimalsCD8-Positive T-LymphocytesCell Line, TumorGastrointestinal MicrobiomeHumansIndolesMiceMice, Inbred C57BLIndolesTryptophananti-tumor immunityBacteroides rodentiumBacteroides uniformisindolesmelanomatryptophan

Identifiers

PMID42447866
PMCPMC13400165

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.