ArticleJournal of proteome research2026
Analysis and Annotation of c-Type Ions in Peptide Mass Spectral Libraries.
Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The large collection of high-quality mass spectra in the NIST Human HCD Peptide and NIST Tandem Mass Spectral Libraries is used to understand the role of peptide sequence in c-type ion formation in beam-type collision-induced dissociation. Furthermore, results from the analyses were used to inform and apply annotation rules for c-type ions in the updated Human HCD Peptide Mass Spectral Library. As a result, 155,663 c-type ions are now annotated, providing additional peptide sequence information, often where b- and y-type ions may be lacking. Examples shown here highlight the significance of these c-type ions, both in terms of their relative abundance and in resolving peptide-sequence ambiguities. Furthermore, these examples illustrate the value of including c-type ions to improve searching and scoring of peptide spectrum matches.
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