ArticleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica2026
Can We Foresee Grade and Stage Progression in Mixed Low- and High-Grade Noninvasive Papillary Urothelial Carcinomas?
Article in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correction to "Can We Foresee Grade and Stage Progression in Mixed Low- and High-Grade Noninvasive Papillary Urothelial Carcinomas?"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noninvasive papillary urothelial carcinoma (NIPUC), currently classified in a two-tier system, frequently exhibits mixed low- and high-grade morphology. We aimed to determine the impact of histopathologic features on grade and stage progression in mixed NIPUCs. Primary and follow-up bladder specimens (n = 106) of 28 patients diagnosed with mixed NIPUC were retrieved. Pathological parameters included biopsy volume, percentages of 2-tier (low-high) and 4-tier (Grade 1-4) grades, discohesion, and whirling. Outcome measures were grade trend (decline or incline) and stage progression. The mean age was 65 (range, 35-81); all but two were male. Ten patients had a previous biopsy showing pure low-grade NIPUC. Patients with > 5% high-grade areas (n = 14) were classified as high-grade. The mean distributions of G1-G4 in mixed NIPUCs at zero-point were 42%, 42%, 15%, and 1%, respectively. Tumors with > 85% Grade 1 histology didn't exhibit an upward grade trend. Stage progression was significantly associated with tumors containing ≥ 5% Grades 3-4 (high-grade) areas (p = 0.031). Grade trend was directly correlated with stage progression (p = 0.012). Mixed NIPUC has heterogeneous clinical outcomes: a high proportion of Grade 1 areas (> 85%) predicts a non-inclining grade trend, whereas the presence of ≥ 5% high-grade (Grades 3 and 4) morphology suggests future stage progression.
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