ReviewProceedings (Baylor University. Medical Center)2026
Thyroid tissue in cervical lymph nodes: clinical significance, management, and review of the literature.
Review in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Thyroid tissue in cervical lymph nodes: is it always malignant, and why do we care?Proceedings (Baylor University. Medical Center) · 2026Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhen thyroid tissue is found within a cervical lymph node, clinicians must distinguish between a benign ectopic inclusion (thyroidosis) and metastatic thyroid carcinoma-a distinction with major management implications. This narrative review synthesizes the available literature on benign thyroid tissue incidentally identified in cervical lymph nodes.
methodsA focused literature search was conducted using the PubMed/MEDLINE database with an end date of April 15, 2026. Publications were included if they reported cases of benign thyroid tissue identified in cervical lymph nodes with histological or molecular confirmation, encompassing case reports, case series, or original studies.
resultsFifteen publications were identified, covering approximately 35 to 45 cases. Patients ranged in age from 13 to 72 years (mean 46), with a marked female predominance (∼75%). Lateral cervical nodes (levels II-IV) were involved in ∼80% of cases. Histologically, benign inclusions were characterized by well-formed follicles with colloid, capsular or subcapsular positioning, and no malignant cytology. Immunohistochemical markers (e.g., HBME-1, CK19) and molecular testing (BRAF/RAS mutation analysis) were reported to be helpful in differentiating benign from malignant thyroid tissue. Associated conditions included autoimmune thyroiditis, head and neck malignancies, and postablative states. Over follow-up periods of 6 months to 10 years, no malignant transformation was observed.
conclusionRigorous histological evaluation, supported by ancillary testing, enables confident diagnosis. Conservative surveillance-rather than thyroidectomy-is appropriate when malignancy has been excluded.
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