ArticleRespiration; international review of thoracic diseases2026
Sex Differences in Long-Term Survival of Chronic Obstructive Pulmonary Disease Patients following Initiation of Home Noninvasive Ventilation after Acute Hospitalization due to Respiratory Failure.
Article in Respiration; international review of thoracic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionHome noninvasive ventilation (HNIV) is an established therapy for chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. However, outcomes following HNIV initiation after discharge from the hospital after acute COPD exacerbation remain poorly investigated, in particular sex-related factors.
methodsWe conducted a single-center, retrospective cohort study on COPD patients admitted to our respiratory care unit (RCU) for acute exacerbation with respiratory failure who were discharged home with newly established HNIV between 2013 and 2019. The primary endpoint was all-cause mortality after discharge from RCU. Sex-stratified survival analysis was performed using Kaplan-Meier curves, Cox proportional hazards models, and interaction models incorporating sex and clinical covariates, including lung function test and blood gases assessed at discharge.
resultsA total of 84 patients fulfilled all inclusion and exclusion criteria. The median age was 74 (IQR: 68-77) years, the male-to-female ratio was 1.4:1, and the median forced expiratory volume in 1 s (FEV
conclusionIn COPD patients released home with newly established HNIV after hospitalization for acute exacerbation with respiratory failure, even after adjustment for established clinical covariates, female sex was associated with worse survival. FEV
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