Evidence map›Paper›PMID 42447070›Full record

ArticlePLoS pathogens2026

Structural basis of a conserved, broad antigenic region surrounding the five-fold axis of foot-and-mouth disease virus revealed by swine neutralizing antibodies.

Qiongqiong Zhao, Shanquan Wu, Fengjuan Li, Lv Lv, Shulun Huang, Jiaxin Yang, Zhanhui Zhu, Ying Sun, Pinghua Li, Yimei Cao and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Qiongqiong ZhaoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0009-0006-4934-4738
Shanquan WuSchool of Physical Science and Technology, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou, China.
Fengjuan LiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Lv LvState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Shulun HuangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jiaxin YangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zhanhui ZhuSchool of Physical Science and Technology, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou, China.
Ying SunState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Pinghua LiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Yimei CaoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Huifang BaoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Pu SunState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Xingwen BaiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zhixun ZhaoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jing ZhangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jinyan WuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Hong YuanState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jijun HeState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Xiangmin LiNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-1412-5069
Zengjun LuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0001-9138-692X
Dongsheng LeiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0003-1640-0693
Kun LiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0001-8307-634X

Funding

Innovation Program of Chinese Academy of Agricultural SciencesJoint-Foundation of Gansu province, ChinaNational Natural Science Foundation of ChinaOpen Project Program of Jiangsu Key Laboratory of Zoonosis
6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) exhibits extensive antigenic diversity and limited cross-protection among different serotypes, making the identification of broadly neutralizing antibodies (bnAbs) critical for the development of vaccines that confer broad and effective protection. Here, we isolated four porcine-derived bnAbs that broadly neutralized multiple representative strains from FMDV serotypes O and A. These bnAbs convergently target a conserved antigenic region, with residue 204 (K) towards the VP1 C-terminus serving as a key determinant. Notably, the bnAb pO18-10, which competes with antibodies recognizing the VP1 G-H loop, VP1 C-terminus, and VP3 epitopes, exhibits the broadest neutralization breadth, including cross-neutralization against serotype Asia1. Cryo-electron microscopy (cryo-EM) of pO18-10 in complex with FMDV serotype O (O/18074) revealed a novel cross-protomer antigenic region located around the icosahedral five-fold axis of the viral capsid, with an interaction footprint of up to 1452 Ų. pO18-10 engages this epitope through interactions with the VP1 C-terminus and VP3 G-H loop of one protomer, as well as the VP1 E-F loop of an adjacent protomer, demonstrating extensive antigenic coverage. Residues 204 (K) and 210 (K) on VP1 were identified as key determinants of this cross-serotype antigenic site. Furthermore, pO18-10 sterically blocks the integrin receptor αvβ6, effectively neutralizing FMDV by preventing viral attachment. In vivo, pO18-10 conferred robust prophylactic and therapeutic protection against FMDV-induced mortality and clinical disease in mice. Collectively, these findings provide a promising neutralizing antibody candidate for immunodiagnostic applications and define a cross-serotype antigenic structure for universal FMDV vaccine design.

Indexed as

Antibodies, NeutralizingAntibodies, ViralAntigens, ViralFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusAnimalsCapsid ProteinsCryoelectron MicroscopyEpitopesSwineAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCapsid ProteinsEpitopes

Identifiers

PMID42447070
PMCPMC13367737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.