Evidence map›Paper›PMID 42446982›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Many AI analysts, one dataset: Navigating the agentic data science multiverse.

Martin Bertran, Riccardo Fogliato, Zhiwei Steven Wu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martin Bertran *Amazon, Seattle, WA 98109.
Riccardo Fogliato *Amazon, Seattle, WA 98109.
Zhiwei Steven Wu *Amazon, Seattle, WA 98109.ORCID 0000-0002-8125-8227

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Empirical conclusions depend not only on data but also on analytic decisions. Many-analyst studies have quantified this dependence: independent teams testing the same hypothesis on the same dataset regularly reach conflicting conclusions. But such studies require costly human coordination. We show that fully autonomous AI analysts built on large language models (LLMs) can, cheaply and at scale, produce the analytic dispersion observed in human many-analyst studies. In our framework, each AI analyst independently executes a complete analysis pipeline on a fixed dataset and hypothesis; a separate AI auditor screens every run for methodological validity. Across three datasets, AI analyst-produced analyses exhibit substantial dispersion in effect sizes, [Formula: see text]-values, and conclusions. This dispersion can be traced to identifiable analytic choices in preprocessing, model specification, and inference that vary systematically across LLM and persona conditions. Critically, the outcomes are steerable: reassigning the analyst persona or LLM shifts the distribution of results even among methodologically sound runs. These results highlight a central challenge for AI-automated empirical science: when defensible analyses are cheap to generate, evidence becomes abundant and vulnerable to selective reporting. The same capability also helps address it: treating analyst results as distributions makes analytic uncertainty visible, and deploying AI analysts against a published specification can reveal how much disagreement stems from underspecified design choices. Taken together, our results motivate a transparency norm: AI-generated analyses should be accompanied by multiverse-style reporting and full disclosure of the prompts used, on par with code and data.

Indexed as

AI agentsdata sciencelarge language modelsmultiverse analysisresearch reproducibility

Identifiers

PMID42446982
PMCPMC13393493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.