Evidence map›Paper›PMID 42446935›Full record

ArticleJCI insight2026

Matrikines dictate the amplitude of inflammation in smoke-related Streptococcus pneumoniae pulmonary infection.

Sarah W Robison, Jindong Li, Kristopher R Genschmer, Liliana Viera, Jeremy B Foote, Landon Wilson, W Edward Swords, J Edwin Blalock, Amit Gaggar, Xin Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah W RobisonSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jindong LiSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kristopher R GenschmerSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Liliana VieraSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jeremy B FooteSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Landon WilsonSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
W Edward SwordsSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Edwin BlalockSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Amit GaggarSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Xin XuSchool of Medicine and Lung Biology Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Funding

Pathogenic Exosomes in COPDR35HL166433 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI J Edwin Blalock · 2023 to 2026
$4.1M
A Pathogenic Smoke Associated Neutrophilic Exosomal Pathway.R01HL162705 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kristopher R. Genschmer · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL162705NHLBI NIH HHS R35 HL166433
6 · The paper itself

Abstract

Smoking remains a major risk factor for the severity of bacterial pneumonias, although mechanisms driving this injury remain poorly understood. This manuscript provides a new insight on how the smoke-exposed lung and bacteria augment the release of enzymes capable of directly damaging pulmonary tissue, leading to worsening inflammation and tissue damage.

Indexed as

InflammationPneumonia, PneumococcalSmokingStreptococcus pneumoniaeAnimalsHumansLungMiceNeutrophilsInflammationNeutrophilsProteasesPulmonology

Identifiers

PMID42446935
PMCPMC13502163

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.