Evidence map›Paper›PMID 42446780›Full record

ArticleJournal of molecular histology2026

Comparative pre- and post-treatment effects of aqueous Zingiber officinale Lsfunction in wistar rats: insights into NF-κB, Nrf2, and caspase-3 pathways.

Ezinne Obioma Onigbo, Ukoha Ukoha, Collins Nduka Esomchi, Kelechi Emmanuel Ichie

Erratum issuedAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ezinne Obioma OnigboDepartment of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria. goodziny@gmail.com.ORCID http://orcid.org/0009-0000-4151-0750
Ukoha UkohaDepartment of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.ORCID http://orcid.org/0000-0001-5149-8628
Collins Nduka EsomchiDepartment of Human Anatomy, Faculty of Basic Medical Sciences, State University of Medical and Applied Sciences, Igbo-Eno, Enugu State, Nigeria.ORCID http://orcid.org/0000-0002-5150-5127
Kelechi Emmanuel IchieDepartment of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.ORCID http://orcid.org/0009-0003-1349-8119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cadmium (Cd) is a highly toxic heavy metal that accumulates in the kidney, causing oxidative stress, inflammation, apoptosis, and renal dysfunction. Ginger (Zingiber officinale) possesses antioxidant and anti-inflammatory properties, but comparative studies evaluating pre-treatment versus post-treatment regimens against cadmium nephrotoxicity remain limited. This study investigated the nephroprotective effects of aqueous Z. officinale rhizome extract in a comparative pre- and post-treatment design using histopathological, immunohistochemical, and molecular approaches. Thirty adult male Wistar rats were divided into five groups (n = 6): Control, CdCl₂ (5 mg/kg), Ginger alone (300 mg/kg), CdCl

Indexed as

Caspase 3NF-E2-Related Factor 2NF-kappa BPlant ExtractsSignal TransductionZingiber officinaleAnimalsAntioxidantsCadmiumKidneyMaleRatsRats, WistarAntioxidantsCadmiumCaspase 3Nfe2l2 protein, ratNF-E2-Related Factor 2NF-kappa BPlant ExtractsCadmium nephrotoxicityNephroprotectionNF-κBNrf2Pre-treatmentZingiber officinale

Identifiers

PMID42446780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.