Evidence map›Paper›PMID 42446727›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Advances in the development of N-acylbenzo[d][1,2,3]diazaborinin-1(2H)-ols as antibacterial agents by synthesis, characterization, and antimicrobial assay.

Chloe A Woods, Betty Gutierrez, Naidine Aguinaldo, Prince Kanukwa, Yutong Li, Bethany Hubbard, Juan Daniel Avila, Anthony Jones, Fatime Sebok, Michael P Groziak and 5 more

Abstract read
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In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chloe A WoodsDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Betty GutierrezDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Naidine AguinaldoDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Prince KanukwaDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Yutong LiDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Bethany HubbardDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Juan Daniel AvilaDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Anthony JonesDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Fatime SebokDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA.
Michael P GroziakDepartment of Chemistry and Biochemistry, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA, 94542-3089, USA. michael.groziak@csueastbay.edu.ORCID http://orcid.org/0000-0001-8432-6072
Phattananawee NalaohDepartment of Chemistry, The University of Tennessee, 1420 Circle Drive, Knoxville, TN, 37996-1600, USA.ORCID http://orcid.org/0000-0002-8470-3322
David M JenkinsDepartment of Chemistry, The University of Tennessee, 1420 Circle Drive, Knoxville, TN, 37996-1600, USA.ORCID http://orcid.org/0000-0003-2683-9157
Matthew B CarbajalDepartment of Biological Sciences, California State University, Los Angeles, 5151 State University Dr., Los Angeles, CA, 90032-8201, USA.
Heidi T ChowDepartment of Biological Sciences, California State University, Los Angeles, 5151 State University Dr., Los Angeles, CA, 90032-8201, USA.
H Howard XuDepartment of Biological Sciences, California State University, Los Angeles, 5151 State University Dr., Los Angeles, CA, 90032-8201, USA.ORCID http://orcid.org/0000-0003-4540-8539

Funding

Army Research Office W911NF-12-1-0059California State University, East Bay RSCA Faculty Support GrantsNational Science Foundation MRI 0420615NIH HHS NIGMS SC3GM83686University of Tennessee Ziegler Fund
6 · The paper itself

Abstract

The ability of bacteria to quickly adapt to environmental stresses, such as exposure to antimicrobial drugs, has necessitated a continued search for novel antibacterial agents with new mechanisms of attack, forever in competition with the rate of adaptation of these pathogens. Antibiotic resistant strains of a multitude of infectious diseases have appeared, imposing a huge burden from diseases once believed to have been reduced to minor health issues. Building on prior work, twenty-one new N-acyl-1-hydroxy-2,3,1-benzodiazaborinines were synthesized and characterized by high-field NMR, FTIR, ESI-MS, and other methods including X-ray crystallography for one unexpected structure. The syntheses by direct condensation using acylhydrazides gave products found to exist in one of three structural forms connected by (de/re)hydration reactions: open hydrazone (a), boron heterocycle (b), and anhydro dimer (c). Multisolvent

Indexed as

Anti-Bacterial AgentsBoron CompoundsCrystallography, X-RayEscherichia coliMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsBoron CompoundsAcylhydrazideAntibacterialBoron heterocycleEscherichia coliNMR

Identifiers

PMID42446727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.