ArticleAnnals of hematology2026
UGT1A1 polymorphisms and gallbladder-related outcomes in sickle cell disease in Brazil.
Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallbladder complications represent a significant source of morbidity in sickle cell disease, with UGT1A1 promoter polymorphisms associated with a higher frequency of hyperbilirubinemia and cholelithiasis in affected patients and the first publications regarding this issue appeared in the literature in early 2000. There are at least three published papers providing evidence that supports this association in the Brazilian population published in 2003, 2017 and 2021. Belisário et al., very recently published a paper in Annals of Hematology ("Laboratory and genetic characteristics associated with gallbladder-related outcomes in sickle cell disease in Brazil: results from the REDS-III multicenter cohort study." Annals of Hematology. 2026; 105(4):115) in which they claim that it is the first study in Brazilian population concerning this issue. In our opinion the previous published papers should be cited in the References, because certainly will provide readers with a more accurate and complete picture of the field´s evaluation in Brazil.
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Registered trials
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