ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Changes in iris microvasculature after horizontal strabismus surgery: anterior segment OCTA combined with synoptophore-based functional assessment.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo characterize short-term dynamic changes in iris microcirculation after horizontal strabismus surgery and to explore their associations with postoperative binocular visual function.
methodsIn this prospective self-controlled study, 71 eyes from 56 patients who underwent horizontal rectus muscle surgery at Shanxi Provincial Eye Hospital between June and October 2025 were enrolled (one-muscle group: 17 eyes; two-muscle group: 54 eyes). Anterior segment OCT angiography was performed 1 day before surgery and at 1 day, 2 weeks, and 6 weeks postoperatively to quantify iris vessel density (VD), iris vessel skeleton density (VSD), and iris perfusion area (PA). Synoptophore testing was used to assess simultaneous perception/fusion grades, and near stereopsis was assessed with the Titmus test. Linear mixed-effects models were applied to examine associations between functional variables and OCTA metrics.
resultsIris VD and VSD exhibited reversible short-term fluctuations after surgery, with larger changes in the two-muscle group, whereas PA remained relatively stable. From postoperative week 2 onward, simultaneous perception, fusion, and stereopsis generally improved. Mixed-effects modeling indicated negative associations of the number of operated muscles with VD and VSD, and positive associations of simultaneous perception/fusion with VSD. No significant correlation was found between Titmus stereopsis and OCTA parameters.
conclusionsHorizontal strabismus surgery is associated with subclinical, reversible short-term alterations in iris microcirculation. The association between iris OCTA parameters, particularly VSD, and synoptophore grade I/II function suggests that these metrics may provide complementary information during postoperative functional assessment; however, binocular recovery remains influenced by ocular alignment and other sensory factors.
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