ArticleArchives of toxicology2026
Comparative in vitro study of structure related uptake of ten perfluoroalkyl substances by human and rat renal transporters.
Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Understanding the renal mechanisms underlying per- and polyfluoroalkyl substances (PFASs) elimination is critical to explain species- and structure-dependent toxicokinetic (TK) differences. This study investigated the in vitro uptake of ten PFASs, including perfluoroalkyl carboxylic acids (PFCAs) and sulfonic acids (PFSAs) with carbon chain lengths ranging from 4 to 10, as well as emerging PFASs (GenX, PFO2OA), by eight human and four rat homologous renal transporters using in vitro cell-based assays. Results showed that Organic Anion Transporter 1 (OAT1) specifically mediated PFHxA uptake and identified PFCAs up to nine carbons (PFHxA, PFOA, PFNA) and PFSAs up to six carbons (PFBS and PFHxS) as likely substrates of human OAT3 and OAT4. In rats, Oat1 and Oatp1a1 mediated the transport of these short- and medium-chain PFASs. In addition, the emerging PFASs, GenX and PFO2OA, were identified as likely substrates for human OAT3, rat Oat1, and rat Oatp1a1. In contrast, long-chain PFASs (PFDA, PFOS, PFDS) were not substrates for any tested transporter in either species. Uptake of short- and medium-chain PFASs by human OAT1, OAT3, and rat Oat1, located on the basolateral membrane, supports their roles in active secretion, whereas their interaction with human OAT4 and rat Oatp1a1, in the apical membranes of proximal tubular cells, indicates a potential contribution to tubular reabsorption. The comparable PFAS chain-length threshold for the uptake of PFASs by homologous human and rat renal transporters suggests that additional mechanisms may account for interspecies differences in PFAS renal clearance.
Indexed as
Identifiers
42446666What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.