Evidence map›Paper›PMID 42446654›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Structural modification of (‒)-xanthorrhizol isolated from Curcuma aromatica rhizomes to analogs with potent nitric oxide inhibitory activities.

Wachirachai Pabuprapap, Waraluck Chaichompoo, Porawan Pratumwan, Monsin Sangsawat, Nassareen Supaweera, Warangkana Chunglok, Agung Rahmadani, Vachiraporn Ajavakom, Pornchai Rojsitthisak, Apichart Suksamrarn

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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wachirachai PabuprapapDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-6445-7550
Waraluck ChaichompooDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand. waraluck.c@rumail.ru.ac.th.ORCID http://orcid.org/0000-0002-6359-5828
Porawan PratumwanHealth Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0009-0009-8116-2581
Monsin SangsawatDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.ORCID http://orcid.org/0009-0006-7629-0376
Nassareen SupaweeraHealth Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0001-8583-0262
Warangkana ChunglokSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0002-8000-6052
Agung RahmadaniDepartment of Chemistry Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, 75123, East Kalimantan, Indonesia.ORCID http://orcid.org/0009-0001-2301-5892
Vachiraporn AjavakomDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-8730-9286
Pornchai RojsitthisakDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.ORCID http://orcid.org/0000-0003-1391-6993
Apichart SuksamrarnDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-8919-3555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(‒)-Xanthorrhizol (1), a natural sesquiterpenoid isolated from Curcuma aromatica rhizomes, exhibits notable anti-inflammatory activity by inhibiting nitric oxide (NO) production. To enhance its NO inhibitory activity, a series of 22 analogs were synthesized through chemical modifications, including alkylation, esterification, hydrogenation, oxidation, and oximination. The NO inhibitory activities of these analogs were evaluated in LPS-stimulated RAW264.7 macrophage cells using the Griess method, while cytotoxicity was assessed with the MTT assay. Among the tested compounds, the oxime analog 23 demonstrated the strongest NO inhibitory activity (IC

Indexed as

CurcumaNitric OxidePhenolsRhizomeAnimalsAnti-Inflammatory AgentsDose-Response Relationship, DrugLipopolysaccharidesMacrophagesMiceMolecular StructureRAW 264.7 CellsStructure-Activity RelationshipAnti-Inflammatory AgentsLipopolysaccharidesNitric OxidePhenolsxanthorrhizolAnti-inflammatory activityCurcuma aromaticaNitric oxide inhibitionStructure–activity relationshipXanthorrhizol analogs

Identifiers

PMID42446654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.