ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026
Anticancer activity of amide and ester derivatives of the ent-labdane 2α-hydroxyeperuic acid obtained via sonochemical synthesis.
Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Medicinal plants are an invaluable source of specialized metabolites with unique and complex chemical structures. This chemical diversity offers a rich resource for discovering new compounds with therapeutic potential. One notable example is Ageratina petiolaris, which produces a mixture of esters of 2α-hydroxyeperuic acid (1) in high quantity. The ent-labdane 2, a product of the alkaline hydrolysis of 1, possesses a chemical structure with promising therapeutic potential. In this work, aniline, cyclohexylamine, 4-chloroaniline, bencilamine, p-cinnamyl alcohol, phenol, 4-bromophenol, and 4-methoxyphenol were used to prepare ester and amide derivatives of 2 in a one-pot process aided with sonochemistry, yielding the respective compounds in moderate to good yields. Additionally, the antiproliferative potential of the amides and esters was tested in vitro against MCF-7, HeLa, A549, and K562 cancer cell lines. The results showed significant cytotoxic activity for almost all the evaluated derivatives, making them promising candidates for potential therapeutic agents against certain types of cancer.
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