ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026
Acylhydrobenzoquinones influence the susceptibility of Staphylococcus aureus towards abietanes and the speciation within Plectranthus sensus lato.
Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bioactive Compounds ofMolecules (Basel, Switzerland) · 2026Review
- Mapping antimicrobials in plant lineages.Frontiers in plant science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genus Plectranthus sensu lato is known to produce abietanes, which exhibit significant potency against Gram-positive bacteria. It is hypothesized that abietanes exert their antibacterial effects by disrupting microbial cell walls. Recent studies have classified Plectranthus s.l. abietanes into six distinct groups. However, the impact of this chemical diversity on the response of abietanes against Gram-positive bacteria remains unexamined. Therefore, a structure-activity relationship study on abietanes from species of Plectranthus sensu stricto and Coleus was conducted to identify active fragments or pharmacophores in abietane-type diterpenoids that could be responsible for their activity against the Gram-positive bacteria Staphylococcus aureus. The study followed a bio-guided approach and included chemical profiling of the extracts, performed using NMR spectroscopy, and comparative analysis, using LC-MS in both positive and negative ionization modes. Results revealed all six classes of abietanes occurred as major constituents of the extracts, with distinctive chemical markers differentiating between Plectranthus s.s. and Coleus species. Oxidation of the B-ring in acylhydrobenzoquinones was identified as a key factor contributing to the strong antibacterial activity of Plectranthus s.l. derived compounds against S. aureus. Analysis of 28 species of Plectranthus s.l. revealed four main clusters based on the accumulation of various abietane classes. The active acylhydrobenzoquinones were a defining factor in the separation of one of the groups of plants while another cluster in both Plectranthus s.s. and Coleus separated based on flavonoid contents. It would be of interest to examine how this trend might be broadened to encompass all species within each genus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.