Evidence map›Paper›PMID 42446622›Full record

ArticleClinical journal of gastroenterology2026

Adenocarcinoma with enteroblastic differentiation with choriocarcinoma components arising in long-segment Barrett's esophagus: a report of autopsy case.

Yuki Sato, Tomio Arai, Kazushi Fukagawa, Yusuke Horikoshi, Kazushi Masatani, Shun Osumi, Shosuke Hosaka, Toshiyuki Ishiwata, Satoshi Ono

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuki SatoDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.
Tomio AraiDepartment of Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Kazushi FukagawaDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan. tw225kaz@gmail.com.ORCID http://orcid.org/0000-0002-7216-6435
Yusuke HorikoshiDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.
Kazushi MasataniDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.
Shun OsumiDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.
Shosuke HosakaDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.
Toshiyuki IshiwataResearch Team for Geriatric Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Satoshi OnoDepartment of Gastroenterology and Gastrointestinal Endoscopy, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenocarcinoma with enteroblastic differentiation (AED) commonly develops in the stomach but rarely occurs at the lower esophagus or esophagogastric junction. This tumor may combine with another subtype such as neuroendocrine carcinoma, conventional adenocarcinoma, and so on. An 87-year-old male patient was admitted to our hospital because of anorexia. Esophagogastroduodenoscopy performed to investigate the cause of anorexia revealed a nearly circumferential elevated lesion at the lower esophagus and esophagogastric junction. Biopsy results showed AED with small foci of choriocarcinoma components. A CT scan showed multiple liver metastases. The patient died 11 days after admission due to hematemesis and hypovolemic shock. Autopsy demonstrated hemorrhage from the tumor, and 700 mL of blood had accumulated in the stomach, being a direct cause of death. As long-segment of Barrett's esophagus (LSBE) was observed in the background of the tumor, the tumor was considered to originate from LSBE. The tumor also extended along the intraesophageal and azygos veins and metastasized to the liver and lung. These results suggest that a peculiar type of carcinoma with aggressive biological behavior occurs in the LSBE.

Indexed as

AdenocarcinomaBarrett EsophagusChoriocarcinomaEsophageal NeoplasmsAged, 80 and overAutopsyFatal OutcomeHumansLiver NeoplasmsMaleAdenocarcinoma with enteroblastic differentiationAlpha-fetoproteinChoriocarcinomaLong-segment Barrett’s esophagus

Identifiers

PMID42446622

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.