ArticleAnalytical and bioanalytical chemistry2026
A Monte Carlo simulation based on first-passage distributions for spatio-temporal detection on potentiometric sensor arrays.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This paper presents a novel simulation approach for particle diffusion that uses Monte Carlo sampling of first-passage distributions to conduct spatio-temporal modelling for potentiometric sensing arrays. The Monte Carlo first-passage (MCFP) simulation algorithm prioritises speed to overcome limitations with currently available techniques. This paper applies the MCFP technique to simulate the detection of protons by arrays of ion-sensitive field-effect transistors (ISFETs) as a case study. The MCFP algorithms were validated against a benchmark random walk algorithm, with temporal MCFP output matching that of the random walk with an average
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