Evidence map›Paper›PMID 42446553›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Discovery of aporphine derivatives with improved antidepressant activity by regulating SERT and 5-HT

Chunyu Wu, Shasha Yue, Benqin Tang, Jianbo Sun

Abstract read
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In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunyu WuState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Shasha YueState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China.
Benqin TangResearch Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, 999077, China. tangbenqincy@gmail.com.
Jianbo SunState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China. sunjianbo@cpu.edu.cn.

Funding

National Natural Science Foundation of China 82173708Natural Science Foundation of Jiangsu Province BK20242072
6 · The paper itself

Abstract

Fifteen novel regulators targeting 5-HT

Indexed as

Antidepressive AgentsAporphinesDrug DiscoveryReceptor, Serotonin, 5-HT2ASerotonin Plasma Membrane Transport ProteinsAnimalsCell ProliferationDepressionMaleMiceMolecular Docking SimulationPC12 CellsRatsStructure-Activity RelationshipAntidepressive AgentsaporphineAporphinesReceptor, Serotonin, 5-HT2ASerotonin Plasma Membrane Transport Proteins5-HT2ARAntidepressantsAporphine alkaloidsNO donorsSERT

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.