Evidence map›Paper›PMID 42446551›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

SAR exploration for 4-aminotetrahydroquinazolines with adamantyl moiety against orthoflaviviruses.

Sergey V Kositov, Evgeny V Khvatov, Victoria I Uvarova, Kseniya N Sedenkova, Alexander S Goryashchenko, Maria K Kaleda, Aleksandra V Peisikova, Yuri K Grishin, Boris P Gladkikh, Gennady M Butov and 3 more

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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sergey V KositovDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.
Evgeny V KhvatovChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia.ORCID http://orcid.org/0000-0002-7493-8523
Victoria I UvarovaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia.ORCID http://orcid.org/0000-0003-0331-9933
Kseniya N SedenkovaDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID http://orcid.org/0000-0002-0294-9581
Alexander S GoryashchenkoChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia.
Maria K KaledaChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia.
Aleksandra V PeisikovaDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.
Yuri K GrishinDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia.ORCID http://orcid.org/0000-0001-7709-5245
Boris P GladkikhVolzhsky Polytechnic Institute (branch) of Volgograd State Technical University, Volzhsky, Volgograd Region, Russia.ORCID http://orcid.org/0000-0001-6271-0479
Gennady M ButovVolzhsky Polytechnic Institute (branch) of Volgograd State Technical University, Volzhsky, Volgograd Region, Russia.ORCID http://orcid.org/0000-0002-0839-4513
Dmitry I OsolodkinChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia. osolodkin_di@chumakovs.su.ORCID http://orcid.org/0000-0002-0462-2945
Aydar A IshmukhametovChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia.ORCID http://orcid.org/0000-0001-6130-4145
Elena B AverinaDepartment of Chemistry, Lomonosov Moscow State University, Moscow, Russia. elaver@med.chem.msu.ru.ORCID http://orcid.org/0000-0002-6107-2003

Funding

Chumakov FSC R&D IBP RAS (Institute of Poliomyelitis) fundamental research assignment № FNZG-2024-0005State assignment of Lomonosov Moscow State University № 121021000105-7
6 · The paper itself

Abstract

4-Aminotetrahydroquinazoline N-oxides form a prominent chemotype of orthoflavivirus reproduction inhibitors, attractive for the search of lead compounds for development as direct-action antiviral agents. Here we explored the relationship between the structure and antiviral activity within an extended series of adamantyl-containing 4-aminotetrahydroquinazolines, synthesized via S

Indexed as

AdamantaneAntiviral AgentsEncephalitis Viruses, Tick-BorneQuinazolinesWest Nile virusAnimalsMolecular StructureStructure-Activity RelationshipAdamantaneAntiviral AgentsQuinazolinesAntiviral agentsAromatic substitutionOrthoflavivirusesStructure-activity relationshipsTetrahydroquinazolines

Identifiers

PMID42446551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.