Evidence map›Paper›PMID 42446418›Full record

ArticleJournal of medicinal chemistry2026

Expanding Addressable KRAS Mutations through the Structure- and Property-Based Design of Dual-State (GDP/GTP), Reversible Pan-KRAS Inhibitors.

Ryan P Wurz, Jennifer R Allen, John G Allen, Albert Amegadzie, Ning Chen, Josephine Eshon, Kexue Li, Xiaofen Li, Yunxiao Li, Francesco Manoni and 37 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Ryan P WurzMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0003-1413-5208
Jennifer R AllenMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
John G AllenMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Albert AmegadzieMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Ning ChenMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Josephine EshonMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Kexue LiMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Xiaofen LiMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Yunxiao LiMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Francesco ManoniMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Jose M MedinaMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Primali NavaratneMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Liping H PettusMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0002-4427-6602
René RahimoffMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
John StellwagenMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Quentin TercenioMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Nicholas WeiresMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Benjamin WigmanMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Michael YamanoMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wei ZhaoMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Gitte HusemoenAmgen Research Copenhagen, Rønnegade 8, Copenhagen DK-2100, Denmark.
Sebastian Leth-PetersenAmgen Research Copenhagen, Rønnegade 8, Copenhagen DK-2100, Denmark.
David BauerDiscovery Process Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Mike J FrohnDiscovery Process Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Olga A MukhinaDiscovery Process Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Michelle BoursierLead Discovery & Characterization, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Amit VaishLead Discovery & Characterization, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0003-1698-0325
Leszek PoppeLead Discovery & Characterization, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0003-1760-6845
Christopher MohrStructural Biology, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Ying-Chu ChenOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Gilbert Joseph DiazOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Kevin GaidaOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Paul E HughesOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Jawahar KhetanOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Deanna MohnOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Tao OsgoodOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Anne Y SaikiOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0003-3913-1860
Karen RexOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Rati VermaOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Paul WangOncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Huan RuiComputational Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Jason YuComputational Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Upendra P DahalPharmacokinetics, Drug Metabolism and Bioanalytical Sciences, Amgen Research, 750 Gateway Boulevard, Suite 100, South San Francisco, California 94080, United States.ORCID 0000-0002-3891-3302
Yanfei LiPharmacokinetics, Drug Metabolism and Bioanalytical Sciences, Amgen Research, 750 Gateway Boulevard, Suite 100, South San Francisco, California 94080, United States.
Prashant AgarwalPre-Pivotal Drug Product, Process Development, Amgen, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0002-7454-5949
Teresa WegesserTranslational Safety and Risk Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Brian A LanmanMedicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.ORCID 0000-0002-8768-7188

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutically targeting mutant KRAS represents a clinically validated approach for the treatment of solid tumors, including lung, colon, and pancreatic cancers. The approval of covalent KRAS

Indexed as

Antineoplastic AgentsDrug DesignGuanosine DiphosphateGuanosine TriphosphateProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorHumansMiceMutationStructure-Activity RelationshipAntineoplastic AgentsGuanosine DiphosphateGuanosine TriphosphateKRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

PMID42446418
PMCPMC13403303

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.