Evidence map›Paper›PMID 42446273›Full record

ArticleAdvanced healthcare materials2026

Neutrophil-Mediated Inflammatory Response to Zinc Bone Implants: A Single-Cell Transcriptomic Landscape.

Mi Du, Qinyang Yan, Chen Zhu, An Li, Jiahao Chen, Huibin Liang, Jiannan Zhou, Ping Li, Jingtao Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mi DuDepartment of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-2237-9918
Qinyang YanDepartment of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China.
Chen ZhuDepartment of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China.
An LiDepartment of Periodontology, School of Stomatology, Stomatological Hospital, Southern Medical University, Guangzhou, China.
Jiahao ChenDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité-Universitätsmedizin, Berlin, Germany.
Huibin LiangDepartment of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China.
Jiannan ZhouDepartment of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China.
Ping LiDepartment of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-0782-6713
Jingtao DaiDepartment of Orthodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.

Funding

82301134 82301084Guangdong Basic and Applied Basic Research Foundation 2022A1515111092Guangdong Medical Science and Technology Research Fund Program A2023108Guangdong Medical Science and Technology Research Fund Program A2023369National Natural Science Foundation of ChinaOpen Foundation of Shandong Key Laboratory of Oral Tissue Regeneration SDKQ202301Open Foundation of Shandong Key Laboratory of Oral Tissue Regeneration SDKQ202302Science and Technology Program of Guangzhou 2025A04J3389
6 · The paper itself

Abstract

Zinc (Zn)-based metals have been considered as promising materials for bone regeneration and repair. Neutrophils, as the initial responders in the acute inflammatory phase, play a critical role by generating specialized mediators that facilitate the natural resolution of inflammation. Nevertheless, the mechanisms governing neutrophil-driven inflammation following the implantation of Zn-based metals are not fully elucidated. This study investigated neutrophil-macrophage crosstalk around Zn-based implants using single-cell transcriptomic profiling. A high-resolution cellular atlas of the peri-implant bone marrow microenvironment was generated in a rat femoral model comparing Zn-based implants with the titanium (Ti) ones. The results revealed that Zn implants induced a distinct neutrophil (Neu) subset heterogeneity, including Cd177

Indexed as

InflammationNeutrophilsProstheses and ImplantsTranscriptomeZincAnimalsMacrophagesMaleRatsSingle-Cell AnalysisTitaniumTitaniumZincbiodegradable metalsimmunomodulationsingle cell transcriptomicstitaniumzinc

Identifiers

PMID42446273
PMCPMC13447904

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.