Evidence map›Paper›PMID 42446245›Full record

ArticleEuropean journal of neurology2026

Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.

Sophie A Froud, Benjamin A Levett, Jessica Jiang, Lucy B Core, Nehzat Koohi, Madison Tutton, Tim Green, Doris-Eva Bamiou, Charles R Marshall, Chris J D Hardy and 1 more

Abstract read
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In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sophie A FroudDementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0009-0002-2535-000X
Benjamin A LevettDementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Jessica JiangDementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Lucy B CoreDementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Nehzat KoohiDepartment of Clinical and Movement Neurosciences, Institute of Neurology, University College London, London, UK.
Madison TuttonEargym Ltd, London, UK.
Tim GreenEargym Ltd, London, UK.
Doris-Eva BamiouNational Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Charles R MarshallCentre for Preventive Neurology, Queen Mary University of London, London, UK.
Chris J D HardyDementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-4900-6492
Jason D WarrenDementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-5405-0826

Funding

Alzheimer's Society 627Alzheimer's Society AS-PG-16-007National Institute for Health and Care Research NIHR204280National Institute for Health and Care Research NIHR302201Royal National Institute for Deaf People G105Royal National Institute for Deaf People PA23_HardyThe National Brain Appeal (Frontotemporal Dementia Research Studentship in Memory of David Blechner)
6 · The paper itself

Abstract

backgroundUnderstanding speech despite background noise is essential for everyday communication, but makes heavy neural processing demands. It is therefore potentially vulnerable to neurodegenerative diseases, particularly those led by communication deficits (primary progressive aphasia). However, how speech-in-noise perception is affected in these diseases is poorly understood.

methodsHere we addressed this in 59 patients representing typical Alzheimer's disease and canonical logopenic, nonfluent/agrammatic and semantic variant syndromes of primary progressive aphasia, compared with 24 cognitively-well, older controls. We administered a digit triplet test of speech-in-noise perception based on the task used in the UK Biobank study, alongside pure tone audiometry and a general neuropsychological assessment. Voxel-based morphometry of patients' brain MRI scans was used to identify structural neuroanatomical associations of speech-in-noise perception.

resultsAfter adjusting for age, peripheral hearing and general cognitive function, the Alzheimer's, logopenic and nonfluent primary progressive aphasia groups performed significantly worse on speech-in-noise perception than controls. The nonfluent primary progressive aphasia and Alzheimer groups additionally had significantly worse peripheral hearing function than controls. Speech-in-noise perceptual performance correlated with grey matter atrophy in the right supramarginal gyrus.

conclusionProfiles of central (brain) and peripheral hearing impairment stratify major dementias, with implications for diagnosis and development of interventions to improve real-world communication in people living with dementia.

Indexed as

Alzheimer DiseaseAphasia, Primary ProgressiveNoiseSpeech PerceptionAgedBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsAlzheimer's diseaseauditory perceptionfrontotemporal dementiaprimary progressive aphasiaspeech perception

Identifiers

PMID42446245
PMCPMC13367126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.