Evidence map›Paper›PMID 42446239›Full record

ArticleMicrobiology spectrum2026

Structural insights into multitargeting

Angelika Pölläniemi, Ya Miao, Lotta Laitila, Hannaleena Piippo, Milka Hammarén, Mataleena Parikka, Teemu Haikarainen

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angelika PölläniemiFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0009-0001-5949-6122
Ya MiaoFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Lotta LaitilaFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Hannaleena PiippoFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Milka HammarénFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0001-9076-8782
Mataleena ParikkaFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Teemu HaikarainenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-8441-2517

Funding

Jane ja Aatos Erkon SäätiöResearch Council of Finland (AKA) 338624Research Council of Finland (AKA) 340572Research Council of Finland (AKA) 348968Research Council of Finland (AKA) 361966State Research Funding, VTRTampereen Tuberkuloosisäätiö
6 · The paper itself

Abstract

Tuberculosis remains one of the leading major global health challenges, driven by the emergence of multidrug-resistant and extensively drug-resistant bacterial strains. Resistant strains complicate treatment, which often requires prolonged use of toxic second- and third-line drugs. Protein phosphorylation plays critical roles in

Indexed as

Antitubercular AgentsBacterial ProteinsMycobacterium tuberculosisProtein Kinase InhibitorsProtein KinasesProtein Serine-Threonine KinasesCrystallography, X-RayHumansMolecular Docking SimulationPhosphorylationProtein Kinase CAntitubercular AgentsBacterial ProteinsPknA protein, Mycobacterium tuberculosisPknB protein, Mycobacterium tuberculosisProtein Kinase CProtein Kinase Inhibitorsprotein kinase NProtein KinasesProtein Serine-Threonine Kinasesantimycobacterialdrug discoveryPkn kinasesX-ray crystallography

Identifiers

PMID42446239
PMCPMC13435872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.