Evidence map›Paper›PMID 42446233›Full record

ArticlemBio2026

Pathway remodeling and adaptive evolution enable efficient co-utilization of glucose and xylose in

Xiaoxu Tan, Yichun Hu, Kai Li, Wensi Meng, Kaiyu Gao, Qiaoyue Yang, Lingru Gong, Leilei Guo, Mengyao Hao, Hongxu Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaoxu TanState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.ORCID 0009-0002-7021-5392
Yichun HuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Kai LiShanghai Changing Biotechnology Co., Ltd, Shanghai, People's Republic of China.
Wensi MengState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.ORCID 0000-0003-4545-8667
Kaiyu GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Qiaoyue YangState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Lingru GongState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Leilei GuoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Mengyao HaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Hongxu ZhangState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Yidong LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Zhaoqi KangState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Cuiqing MaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.ORCID 0000-0002-7468-1027
Chao GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Qianjin KangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Chuanjuan LüState Key Laboratory of Microbial Technology, Shandong University, Qingdao, People's Republic of China.
Ping XuState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.ORCID 0000-0002-4418-9680

Funding

China Postdoctoral Science Foundation 2023M742085China Postdoctoral Science Foundation 2024M751800National Natural Science Foundation of China 32300029National Natural Science Foundation of China 32300045Open Funding Project of State Key Laboratory of Microbial Metabolism MMLKF24-07Postdoctoral Innovation Program of Shandong Province No. SDCX-ZG-202400150Qingdao Postdoctoral Reasearch Project QDBSH20230201011State Key Laboratory of Microbial Technology SKLMTFCP-2023-03Youth Program of Natural Science Foundation of Qingdao City 23-2-1-31-zyyd-jchYouth Program of Natural Science Foundation of Shandong Province ZR2022QC092Youth Program of Natural Science Foundation of Shandong Province ZR2023QC237
6 · The paper itself

Abstract

Efficient co-utilization of glucose and xylose is critical for microbial bioconversion of lignocellulosic hydrolysates. However, carbon catabolite repression prevents simultaneous sugar consumption in conventional industrial strains such as

Indexed as

Escherichia coliGlucoseMetabolic Networks and PathwaysXyloseCatabolite RepressionEscherichia coli ProteinsGene DeletionGlucose-6-Phosphate IsomeraseKlebsiella oxytocaMetabolic EngineeringTranscription FactorsEscherichia coli ProteinsGlucoseGlucose-6-Phosphate Isomerasepgi protein, E coliTranscription FactorsXyloseXylR protein, E coli2,3-butanediolcarbon catabolite repressionEscherichia colilignocellulosic hydrolysatepyruvate

Identifiers

PMID42446233
PMCPMC13464349

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.