Evidence map›Paper›PMID 42446227›Full record

ArticleMicrobiology spectrum2026

Longitudinal analysis of the hand microbiome in response to chlorine-based antiseptic use during a military field exercise.

Susanne Glenna, Einar E Birkeland, Russell J S Orr, Gregor D Gilfillan, Marianne Dalland, Ole Andreas Økstad, Øyvind A Voie, Trine B Rounge

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susanne GlennaSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.ORCID 0000-0002-7730-0138
Einar E BirkelandSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.ORCID 0000-0002-9361-7987
Russell J S OrrNorwegian Defense Research Establishment (FFI), Kjeller, Norway.ORCID 0000-0002-1972-1321
Gregor D GilfillanDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.ORCID 0000-0001-8116-0134
Marianne DallandDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.ORCID 0000-0003-4105-1034
Ole Andreas ØkstadSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.ORCID 0000-0001-9351-8535
Øyvind A VoieNorwegian Defense Research Establishment (FFI), Kjeller, Norway.
Trine B RoungeSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.ORCID 0000-0003-2677-2722

Funding

Norges Forskningsråd (Forskningsrådet) 332591
6 · The paper itself

Abstract

Hand hygiene is essential for infection control, yet the impact of frequent antiseptic use on the skin microbiome, which is crucial for skin barrier function and pathogen exclusion, remains underexplored, especially in field conditions. In high-risk military settings, there is a need for safe, multipurpose antiseptics that avoid the drawbacks of alcohol-based options, including skin irritation, flammability, and unsuitability for wound application. We conducted a longitudinal study during the Norwegian-led military exercise Cold Response 2022 to assess the effects of repeated use of stabilized hypochlorous acid, a non-alcoholic antiseptic, on the hand microbiome of soldiers in a field environment. Participants used either the chlorine-based antiseptic (

Indexed as

Anti-Infective Agents, LocalBacteriaChlorineHandMicrobiotaMilitary PersonnelAdultHand DisinfectionHumansLongitudinal StudiesMaleRNA, Ribosomal, 16SSkinSkin MicrobiomeYoung AdultAnti-Infective Agents, LocalChlorineRNA, Ribosomal, 16S16S rRNA sequencinghand sanitizershygienehypochlorous acidinfection controlmicrobiotamilitary personnelskin microbiome

Identifiers

PMID42446227
PMCPMC13436202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.