Evidence map›Paper›PMID 42446222›Full record

ArticleMicrobiology spectrum2026

Extracellular pneumolysin enhances the activation of cytosolic pattern-recognition receptor NOD2 through its pore-forming activity.

Hisanori Domon, Satoru Hirayama, Toshihito Isono, Tomoki Maekawa, Yutaka Terao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hisanori DomonDivision of Microbiology and Infectious Diseases, Niigata University Graduate School of Medicine, Dentistry and Health Sciences, Niigata, Japan.ORCID 0000-0002-2911-826X
Satoru HirayamaDivision of Microbiology and Infectious Diseases, Niigata University Graduate School of Medicine, Dentistry and Health Sciences, Niigata, Japan.ORCID 0000-0003-0965-8733
Toshihito IsonoDivision of Microbiology and Infectious Diseases, Niigata University Graduate School of Medicine, Dentistry and Health Sciences, Niigata, Japan.ORCID 0000-0002-8676-3302
Tomoki MaekawaCenter for Advanced Oral Science, Niigata University, Graduate School of Medicine, Dentistry and Health Sciences, Niigata, Japan.ORCID 0000-0002-4597-1316
Yutaka TeraoDivision of Microbiology and Infectious Diseases, Niigata University Graduate School of Medicine, Dentistry and Health Sciences, Niigata, Japan.ORCID 0000-0002-4450-5583

Funding

Japan Society for the Promotion of Science JP22K09923Japan Society for the Promotion of Science JP23H00445Japan Society for the Promotion of Science JP23K18355Japan Society for the Promotion of Science JP24K22180Japan Society for the Promotion of Science JP26H02460Japan Society for the Promotion of Science JP26K12616
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsNod2 Signaling Adaptor ProteinReceptors, Pattern RecognitionStreptococcus pneumoniaeStreptolysinsCytosolHEK293 CellsHumansImmunity, InnateInnate Immunity RecognitionNod1 Signaling Adaptor ProteinPeptidoglycanBacterial ProteinsNOD1 protein, humanNod1 Signaling Adaptor ProteinNOD2 protein, humanNod2 Signaling Adaptor ProteinPeptidoglycanplY protein, Streptococcus pneumoniaeReceptors, Pattern RecognitionStreptolysinsinnate immunityNOD2pneumolysinpore-forming toxinStreptococcus pneumoniae

Identifiers

PMID42446222
PMCPMC13435831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.