ArticleMicrobiology spectrum2026
Performance of the Qvella FAST system with downstream application of MALDI-TOF-MS, VITEK 2, and β-LACTA test for same-day identification and antimicrobial susceptibility testing of Gram-negative rods directly from positive blood cultures.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Direct identification (ID) and antimicrobial susceptibility testing (AST) of bacteria from positive blood cultures (BCs) are crucial for rapid optimization of therapy in sepsis. The FAST system purifies a Liquid Colony (LC) from BC broth within 25-35 min for downstream applications. We investigated the performance of the FAST system on BCs growing Gram-negative rods combined with mass spectrometry (MALDI-TOF-MS), the β-LACTA-test, and VITEK 2 AST from LC. VITEK 2 AST results were analyzed after 6 and 8 h, and their impact on empiric antibiotic therapy was examined. We included 119 BCs. MALDI-TOF-MS identified all pathogens correctly. The β-LACTA test detected hydrolyzation of third-generation cephalosporins (
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