Evidence map›Paper›PMID 42446020›Full record

ArticleJournal of food science2026

Exploring Coffee By-Products as Alternative Protein Sources: A Comprehensive Analysis of Amino Acid Profiles (Free and Total) and Protein Quality.

Marlene Machado, Susana Machado, Joana Lobo, Maria Beatriz Oliveira, Helena Ferreira, Rita Carneiro Alves

Abstract read
In one paragraph

Article in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marlene MachadoLAQV - REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-4104-4435
Susana MachadoLAQV - REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-4567-0687
Joana LoboLAQV - REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Maria Beatriz OliveiraLAQV - REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-6767-6596
Helena FerreiraUCIBIO - i4HB, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0001-8465-6346
Rita Carneiro AlvesLAQV - REQUIMTE, Faculty of Pharmacy, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-5053-513X

Funding

FCT/MECI, Fundação para a Ciência e Tecnologia and Ministério da Educação, Ciência e Inovação| Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos UID/50006/2025Fundação para a Ciência e Tecnologia (FCT)/ Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), Portugal PTDC/SAU-NUT/2165/2021
6 · The paper itself

Abstract

In the face of growing concerns about global food security, there is an increasing need to explore unconventional protein sources. This study characterized the protein fraction of six coffee by-products, namely dried pulp, husks, parchment, defective beans, sieving residue, and silverskin. Total and free amino acid composition was determined by RP-HPLC-FLD. Protein quality was evaluated using the amino acid score, essential amino acid index, and biological value. The protein content in the coffee by-products ranged from 1.49% in parchment to 14.34% in silverskin (dry weight). Except for parchment, coffee by-products contained high levels of aspartic acid, glutamic acid, leucine, and proline. Defective beans exhibited the most balanced amino acid content and the highest protein quality (EAAI = 91%). Methionine was the first limiting amino acid. In conclusion, coffee by-products, except parchment, can be considered promising sources of sustainable protein, thereby promoting their valorization within a circular bioeconomy framework.

Indexed as

Amino AcidsCoffeaCoffeePlant ProteinsChromatography, High Pressure LiquidSeedsAmino AcidsCoffeePlant Proteinsamino acid compositionamino acid scorebiological valueessential amino acid indextrue protein

Identifiers

PMID42446020
PMCPMC13366559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.