ArticleFrontiers in cellular and infection microbiology2026
Antibacterial effect of a dental adhesive containing SCH-79797 on
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Antibacterial modification of dental adhesives has emerged as a viable strategy for caries prevention. In this study, a newly identified dual-target antimicrobial, SCH-79797, known for its strong antibiofilm activity, was incorporated into a dental adhesive. Its antibiofilm performance was subsequently evaluated using a Methods: The bonding performance, polymerization behavior and surface wettability of the SCH-79797-modified adhesive were evaluated by shear bond strength testing, degree of conversion, and water contact angle measurements, respectively. Biocompatibility was examined in L929 fibroblasts using CCK-8 assays and live/dead cell staining. Antibacterial activity against biofilms was evaluated through CFU counting, MTT assays, SEM observation, and live/dead bacterial staining. In addition, biofilm virulence was evaluated by analyzing water-insoluble polysaccharide and extracellular polysaccharide (EPS) production, as well as changes in pH and lactic acid production. Results: Incorporating SCH-79797 at concentrations up to 0.5% did not adversely affect the adhesive properties and resulted in minimal cytotoxicity. Compared with the control, the SCH-79797-modified adhesive reduced bacterial viability by approximately 6 log CFU, and significantly decreased lactate production and EPS synthesis by approximately 90% and 90%, respectively. Conclusions: These findings indicate that SCH-79797-modified dental adhesives possess promising
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