ArticleFrontiers in cellular and infection microbiology2026
Development and internal validation of a nomogram for predicting neurobrucellosis in hospitalized patients with brucellosis: a single-center retrospective study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To develop and validate a nomogram based on routinely available clinical indicators for individualized prediction of the risk of neurobrucellosis (NB), thereby providing decision support for early clinical diagnosis and timely treatment while avoiding overtreatment. Methods: A single-center retrospective study was conducted including 407 patients diagnosed with brucellosis and hospitalized at the General Hospital of Ningxia Medical University between January 1, 2020 and September 1, 2025. Demographic characteristics, comorbidities, clinical symptoms, physical signs, and laboratory findings at the time of first hospitalization were collected. The occurrence of NB served as the outcome variable. Univariate logistic regression analysis was first performed to screen potential predictors, and variables with Results: A total of 407 patients with brucellosis were included, comprising 275 males (67.6%) and 132 females (32.4%). The incidence of NB was 10.6% (43/407). Compared with non-neurobrucellosis (non-NB) patients, those with NB were younger and had a lower incidence of bone and joint pain. Additionally, NB patients exhibited higher levels of hemoglobin and albumin, but lower levels of fibrinogen, high-sensitivity C-reactive protein, and erythrocyte sedimentation rate (all Conclusion: The nomogram model developed in this study demonstrated good predictive performance and potential clinical applicability. It may serve as a useful tool for early identification of high-risk patients with neurobrucellosis among individuals with brucellosis, thereby facilitating timely and individualized clinical management.
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