ArticleKidney diseases (Basel, Switzerland)
Risk Factors for Pulmonary Hypertension and Survival in Hemodialysis Patients: Are We Overlooking Serum Magnesium?
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Pulmonary hypertension (PH) is a major complication in patients undergoing maintenance hemodialysis (MHD), significantly elevating the risk of cardiovascular events and mortality and severely impairing quality of life. Methods: In this single-center retrospective study, 1,077 MHD patients were enrolled. PH was diagnosed via echocardiography, and relevant clinical data were collected. Results: The prevalence of PH was 33.8% (364 cases). Nonlinear regression analysis indicated a significant inverse correlation between serum magnesium levels and PH. Notably, the risk of PH increased substantially when serum magnesium fell below 0.98 mmol/L. After adjusting for confounders (age, hemoglobin, serum phosphorus, NT-proBNP, left ventricular ejection fraction, extracellular water ratio, and pleural effusion), patients in the high-magnesium group (≥0.98 mmol/L) exhibited a 49.9% lower risk of PH ( Conclusion: This study provides the evidence that hypomagnesemia is an independent risk factor for PH in MHD patients and is closely associated with adverse clinical outcomes. Management of hypomagnesemia is particularly crucial in MHD patients with PH.
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