Evidence map›Paper›PMID 42445813›Full record

ArticleJournal of asthma and allergy2026

Persistent Airflow Limitation in Asthma: Clinical Characteristics, Risk Factors, and Long-term Outcomes from a Multicenter Cohort Study.

Jung-Kyu Lee, Hyun-Woo Lee, Chang Hoon Lee, Joon Young Choi, Jong Geol Jang, Chin Kook Rhee, Yong Bum Park, Seong Yong Lim, Kwang Ha Yoo, Deog Kyeom Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jung-Kyu LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-5060-7255
Hyun-Woo LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-4379-0260
Chang Hoon LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-9960-1524
Joon Young ChoiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-6298-2204
Jong Geol JangDivision of Pulmonology and Allergy, Department of Internal Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Republic of Korea.ORCID 0000-0001-8040-5363
Chin Kook RheeDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-4533-7937
Yong Bum ParkDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University, Seoul, Republic of Korea.ORCID 0000-0002-5814-6104
Seong Yong LimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-8098-3622
Kwang Ha YooDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-9969-2657
Deog Kyeom KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-1186-3728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Persistent airflow limitation (PAL) is an increasingly recognized asthma phenotype, but its prevalence, determinants, and prognostic significance in real-world settings remain unclear. This study evaluated the clinical characteristics and long-term outcomes associated with PAL and its severity in asthma. Methods: Multicenter analysis of combined retrospective and prospective cohorts in South Korea. PAL was defined as post-bronchodilator FEV Results: Among 849 patients with asthma, 640 (75.4%) had PAL. PAL was associated with older age, male sex, lower body mass index, higher smoking intensity, lower FEV Conclusion: PAL and its severity independently predict the risk of severe exacerbations and progressive lung function decline in asthma, underscoring PAL as a key marker of disease progression and a potential target for early intervention.

Indexed as

asthmaexacerbationlung functionpersistent airflow limitation

Identifiers

PMID42445813
PMCPMC13360822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.