Evidence map›Paper›PMID 42445794›Full record

ArticleFrontiers in nutrition2026

Halting cyst progression in ADPKD using long-term ketogenic metabolic therapy and supplementation with exogenous ketones and alkaline citrate-a case series.

Melina Messing, Emily Muensterman, Serena Marcon, Thomas Weimbs

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melina MessingDepartment of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, United States.
Emily MuenstermanSanta Barbara Nutrients, Inc., Santa Barbara, CA, United States.
Serena MarconDepartment of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, United States.
Thomas WeimbsDepartment of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ADPKD is a progressive cystic disorder characterized by increasing total kidney volume (TKV), declining kidney function, and limited disease-modifying options. Emerging preclinical and clinical evidence suggests metabolic interventions may influence cyst growth, but longitudinal imaging data in humans remain limited. We conducted a retrospective case series of four self-referred individuals (ages 33-71) with genetically confirmed truncating PKD1 variants who independently implemented metabolic interventions of varying duration and intensity, including carbohydrate restriction, intermittent fasting, and supplementation with a ketone- and citrate-based medical food (KetoCitra

Indexed as

chronic kidney diseaseexogenouse ketonesketogenic metabolic therapynutritionpolycystic kidney disease

Identifiers

PMID42445794
PMCPMC13357147

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.