ArticleFrontiers in nutrition2026
The atherogenic index of plasma is associated with subclinical cardiac systolic dysfunction among obese patients: a cross-sectional study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Atherogenic index of plasma (AIP) is a novel and sensitive lipid-related biomarker closely associated with metabolic disorders and cardiovascular risk. Obesity is an independent risk factor for subclinical cardiac systolic dysfunction (SD), while the potential association between AIP and early cardiac systolic impairment in obese populations remains unclear. This study aimed to investigate the relationship between AIP and subclinical cardiac SD in obese adults. Methods: A cross-sectional study was conducted among 1,070 obese patients between 2019 and 2024. Clinical and biochemical parameters of obese patients were collected on the same day as echocardiographic image acquisition. Subclinical cardiac SD was defined via left ventricular (LV) global longitudinal strain (GLS) from speckle-tracking echocardiography. The logarithm of triglycerides/high-density lipoprotein cholesterol ratio is AIP. Patients were stratified by AIP levels, and regression models were constructed to explore the association between the AIP and subclinical cardiac SD in obese patients. Results: After patients were stratified by AIP levels AIP quartiles, the LV GLS absolute value in obese individuals with high AIP levels was significantly reduced compared to obese individuals with low AIP levels ( Conclusion: Elevated AIP is independently associated with subclinical cardiac SD among obese individuals. AIP may serve as a convenient and trustworthy biomarker for early screening of subclinical cardiac SD among obese individuals, which contributes to the early identification and prevention of obesity-related cardiac impairment.
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