Trial reportDrug design, development and therapy2026
A Comparative Study of Pharmacokinetics and Pharmacodynamics of Continuous Ciprofol Infusion Between Young and Elderly Patients.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Precision Sedation for Gastrointestinal Endoscopy in Older Adults: Brain Vulnerability and Recovery.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to systematically compare the pharmacokinetics (PK) and pharmacodynamics (PD) profiles of continuous ciprofol infusion between young and elderly patients under general anesthesia, clarify the impact of age, and provide evidence for precise clinical drug use. Methods: This non-randomised design study enrolled a total of 40 patients scheduled for elective surgery, who were divided into a young group (20-45 years, n=20) and an elderly group (65-85 years, n=20). All participants received ciprofol for anesthesia induction (0.4 mg/kg) and maintenance (0.8 mg/kg/h). Arterial blood samples were collected at 20 predefined time points for plasma concentration analysis using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). PK parameters were determined using non-compartmental analysis. PD endpoints, including bispectral index (BIS) and the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale, were monitored simultaneously. Results: PK analysis revealed that compared with the young group, the elderly group exhibited a significant reduction in total body clearance (CL) of ciprofol (0.60 ± 0.09 vs. 0.75 ± 0.08 L/h/kg, Conclusion: Ciprofol exhibits delayed clearance and increased hemodynamic sensitivity in elderly patients. To achieve safe and effective anesthesia, enhanced intraoperative monitoring and individualized management strategies should be implemented for elderly patients.
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