ReviewFrontiers in cell and developmental biology2026
Advances in porcine stem cell research and their applications in agriculture.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Porcine stem cell research has advanced considerably over the past decade, driven by the dual promise of biomedical modeling and agricultural innovation. This review provides a comprehensive synthesis of recent progress in the isolation, characterization, and directed differentiation of major porcine stem cell types, including embryonic stem cells (pESCs), induced pluripotent stem cells (piPSCs), germline stem cells (pGSCs, spermatogonial stem cells and the controversially debated female germline stem cells), and various adult stem cell populations (e.g., muscle satellite cells, adipose-derived stem cells). We critically analyze persistent challenges that hinder translational applications. For pESCs and piPSCs, achieving stable, germline-competent pluripotency remains challenging. This difficulty arises from species-specific epigenetic roadblocks, such as aberrant DNA methylation and incomplete X-chromosome reactivation, as well as suboptimal culture conditions. For pGSCs, the lack of validated molecular markers for spermatogonial stem cells persists, and the existence of female germline stem cells in postnatal ovaries remains scientifically debated. Focusing on agricultural translation, we examine two key application domains. First, in cultured meat production, porcine muscle and adipose stem cells (or pluripotent stem cell-derived progenitors) are cultivated
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