Evidence map›Paper›PMID 42445664›Full record

ArticleJournal of toxicology2026

A Phenotype-Driven Discovery of Pro-Revascularization Chalcone Derivatives Using Zebrafish and CAM Models.

Yau-Hung Chen, Biswajit Mohanty, Tao-Sheng Li, Sheng-Fen Tung, Chi-Chung Wen, Parthapratim Munshi, Chih-Hsin Chen, Ching-Yuh Chern

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yau-Hung ChenDepartment of Chemistry, Tamkang University, New Taipei City, Taiwan, tku.edu.tw.ORCID https://orcid.org/0000-0003-4436-7464
Biswajit MohantyDepartment of Chemistry, Shiv Nadar Institution of Eminence, Delhi-NCR, Greater Noida, India.ORCID https://orcid.org/0000-0002-6636-3934
Tao-Sheng LiDepartment of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan, nagasaki-u.ac.jp.ORCID https://orcid.org/0000-0002-7653-8873
Sheng-Fen TungDepartment of Chemistry, Tamkang University, New Taipei City, Taiwan, tku.edu.tw.
Chi-Chung WenInstitute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan, cam.ac.uk.
Parthapratim MunshiDepartment of Chemistry, Shiv Nadar Institution of Eminence, Delhi-NCR, Greater Noida, India.ORCID https://orcid.org/0000-0002-3745-9187
Chih-Hsin ChenDepartment of Chemistry, Tamkang University, New Taipei City, Taiwan, tku.edu.tw.
Ching-Yuh ChernDepartment of Applied Chemistry, National Chia-Yi University, Chiayi, Taiwan, ncyu.edu.tw.ORCID https://orcid.org/0009-0002-1554-0176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis is crucial for tissue repair and the treatment of ischemic diseases, yet effective small-molecule proangiogenic agents are lacking in clinical practice. Chalcone-based compounds are of interest due to their diverse biological activities. This study aimed to synthesize and evaluate the proangiogenic potential of a series of novel chalcone derivatives and to elucidate their structure-activity relationship (SAR) using computational chemistry. We synthesized and tested six chalcone derivatives (1a-1f), with compound (

Indexed as

chalconechickpro-angiogenicreal-time PCRSARzebrafish

Identifiers

PMID42445664
PMCPMC13358358

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.