Evidence map›Paper›PMID 42445567›Full record

ArticleEuropean heart journal. Imaging methods and practice2026

Temporal coupling between papillary muscle strain and left ventricular untwisting during diastole.

Nidhal Bouchahda, Fabian Scheipl, Haithem Hbid, Mohamed Yessine Kallela, Meriem Hentati, Mejdi Ben Messaoud, Mezri Maatouk, Aymen Najjar

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Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Nidhal BouchahdaCardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Rue du 1er juin 1955, Monastir 5000, Tunisia.ORCID https://orcid.org/0000-0001-8772-2345
Fabian ScheiplMunich Center for Machine Learning, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
Haithem HbidCardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Rue du 1er juin 1955, Monastir 5000, Tunisia.
Mohamed Yessine KallelaCardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Rue du 1er juin 1955, Monastir 5000, Tunisia.
Meriem HentatiCardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Rue du 1er juin 1955, Monastir 5000, Tunisia.
Mejdi Ben MessaoudCardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Rue du 1er juin 1955, Monastir 5000, Tunisia.
Mezri MaatoukRadiology Department, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
Aymen NajjarCardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Rue du 1er juin 1955, Monastir 5000, Tunisia.ORCID https://orcid.org/0000-0001-8527-1448

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Left ventricular (LV) untwisting is classically considered a passive recoil phenomenon. However, during conditions of shortened diastole, passive mechanisms alone may be insufficient to ensure effective diastolic suction. We hypothesized that both anterolateral papillary muscle (APM) and posteromedial papillary muscle (PPM) contribute actively, alongside passive elastic recoil, to LV untwisting during diastole. Methods and results: In this prospective study, individuals with normal transthoracic echocardiograms underwent two-dimensional speckle-tracking imaging. Longitudinal strain of APM and PPM was obtained, alongside LV torsion measurements. Functional data analysis and penalized function-on-function regression were used to model the temporal association between papillary muscle strain and LV untwisting. A total of 75 patients were enrolled in the study, with a mean age of 37.2 ± 14.9 years. Of these, 16 (21.3%) were female. Hypertension was present in 12 (16%) patients while 7 (9.3%) patients had diabetes. The mean peak torsion measured 25 ± 10 degrees. Maximum contractions of APM and PPM were -17 ± 3.8% and -17 ± 3.7%, respectively. The mean peak LV torsion occurred at 41% of the cardiac cycle and peak global longitudinal strain at 43%, while peak APM and PPM contractions occurred significantly later, at 51% ( Conclusion: Papillary muscles actively contract during diastole and are associated with LV untwisting in a temporally coordinated manner.

Indexed as

cardiac torsiondiastolic functionfunctional data analysisleft ventricular untwistingpapillary muscle strain

Identifiers

PMID42445567
PMCPMC13361982

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.